– Peptides are translated from their specific mRNAs This process is called DNA replication (DNA → DNA), and it is carried out by DNA polymerases.

But DNA codes not only for peptides, but also for other RNA biomolecules with their own function.Īn important corollary of this first postulate is that the information stored in DNA is copied into identical molecules. This information obviously includes the genes that code for proteins. The first postulate of the dogma establishes that all the biological information that specifies the characteristics and potentialities of any living organism is inscribed in its DNA. – The DNA that codes for proteins and other biomolecules

However, from the point of view of the original dogma, not all DNA nor all RNA participates in the DNA → Protein information flow, as established by the latter. The informational biological molecules to which the dogma alludes are deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and proteins (more appropriately, peptides). The original 'dogma' was proposed by Francis Crick in the 1950s, in terms of understanding the process of protein synthesis. History has shown, however, that the flow of genetic information in living things, and viruses, is much more complex than this. That is to say, the flow of genetic information is irreversible and follows the direction DNA → Proteins, never Proteins → DNA. Once it manifests itself in the form of peptides, it cannot be returned. Ultimately, Dogma's emphasis falls on the irreversibility of the flow of biological information. The central dogma of molecular biology establishes the criteria, generally accepted by modern biologists, about the flow of genetic information in living beings, involving both molecules and processes.

– Peptides are translated from their specific mRNAs.

– RNA transcripts carrying the message of a peptide, and other biomolecules.

– The DNA that codes for proteins and other biomolecules.

Video: Central dogma of molecular biology | Chemical processes | MCAT | Khan Academy Content

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